Structured evaluation
Starting with a careful psychiatric history so any interventional pathway, if later considered, sits inside a complete clinical picture.
About us
Our team
Lisa Harding, MD
Dr. Lisa Harding is Medical Director and Founder of Mood Institute and Site Principal Investigator for its clinical research. A board-certified psychiatrist and Assistant Clinical Professor of Psychiatry at Yale, she leads interventional psychiatry programs for complex mood disorders in Milford and Southport, CT. She has completed more than 8,000 interventional procedures.
- Psychiatrist
- Founder
- Site Principal Investigator
Dr. Lisa Harding founded Mood Institute to deliver structured, medically supervised care for people living with depression and other complex mood disorders. She directs clinical programs in Milford and Southport, CT, spanning psychiatric evaluation, medication management, and interventional pathways such as TMS, SPRAVATO®, and IV ketamine.
As Site Principal Investigator she oversees study strategy and conduct for programs described on public registries, including NCT06713616 and NCT06725277, with attention to protocol adherence, safety monitoring, and training of site personnel. She has completed more than 8,000 interventional psychiatry procedures.
Patients can use this background to understand Dr. Harding's experience and prepare questions for the licensed care team.
Qualifications
- Board-certified psychiatrist, American Board of Psychiatry and Neurology
- Medical Director and Founder, Mood Institute
- Site Principal Investigator, Mood Institute clinical research
- Assistant Clinical Professor of Psychiatry, Yale School of Medicine (2023–present)
- Fellow, American Psychiatric Association (2026)
- Connecticut full medical license
Clinical & professional focus
- Treatment-resistant depression
- Interventional psychiatry (TMS, SPRAVATO®, IV ketamine pathways)
- Psychiatric assessment and medication management
- Clinical research leadership as Site Principal Investigator
Education & training
- Doctor of Medicine, Escuela Latinoamericana de Medicina, 2010
- Psychiatry residency, University of Kansas School of Medicine – Wichita
- PGY-4 Chief Resident, Interventional Psychiatric Services, Yale School of Medicine, 2019–2020
- Assistant Clinical Professor / Clinical Preceptor, Yale Physician Assistant Program, 2024–present
Approach to care
Monitored clinic pathways
TMS, SPRAVATO®, and IV ketamine visits are described in published service pages and delivered in a supervised clinic setting.
Research-informed practice
Site Principal Investigator oversight keeps study work inside the same documentation and safety culture as day-to-day care.
Research leadership
- Site Principal Investigator
- Investigator-rater as delegated
Dr. Lisa Harding serves as Site Principal Investigator for Mood Institute clinical research, overseeing study strategy and conduct for interventional and real-world mood-disorder programs listed on public registries, including NCT06713616 and NCT06725277.
Her research-facing work focuses on protocol implementation, participant safety review, staff supervision, and source-documentation quality inside a monitored psychiatric clinic in Milford and Southport, CT.
Research areas & focus
- Treatment-resistant depression
- Interventional psychiatry research
- Comparative effectiveness of racemic ketamine and esketamine (SPRAVATO®)
- Clinic-based study operations
Research certifications & qualifications
- Board Certified Psychiatrist, American Board of Psychiatry and Neurology
- Connecticut Full Medical License
- Fellow, American Psychiatric Association (2026)
- Good Clinical Practice training
- HIPAA compliance training
- REDCap training
- C-SSRS certification (Columbia Lighthouse Project)
Affiliations
- Mood Institute — Medical Director and Founder
- Assistant Clinical Professor of Psychiatry, Yale School of Medicine
- Yale Physician Assistant Program — Clinical Preceptor
Related public studies
- NCT06713616PCORI Study: IV Ketamine vs Esketamine for Treatment-Resistant Depression
- NCT06725277OBSERVE Study: Real-World Outcomes in Depression Care
Study status and eligibility details are maintained on ClinicalTrials.gov. Contact the research team with questions about a listed study.
Published resources
Articles by Lisa Harding, MD
Explore every Mood Institute resource attributed to Lisa.
What interventional psychiatry means in a specialty clinic
Learn what interventional psychiatry includes and how to prepare for a specialty consultation.
Patients & FamiliesQuestions worth bringing about SPRAVATO®, TMS, and ketamine pathways
Use a practical question list to prepare for a SPRAVATO®, TMS, or IV ketamine consultation.
Patients & FamiliesReferring into an interventional psychiatry practice
Prepare an interventional psychiatry referral and keep records and follow-up on the right channels.
Referring ProvidersCollaborating when the medical director is also Site Principal Investigator
Know what to clarify when a specialty clinic’s medical director also oversees studies as Site PI.
Referring ProvidersWhat a Site Principal Investigator does on study days
See what a Site Principal Investigator is responsible for before, during, and after study visits.
Research ParticipantsReading public registry listings for Mood Institute studies
Read the public listings for NCT06713616 and NCT06725277 in a useful order.
Research ParticipantsSite Principal Investigator oversight in a high-volume interventional clinic
A focused first-pass checklist for reviewing Site PI oversight at Mood Institute.
Research SponsorsFolding research into SPRAVATO®, ketamine, and TMS operations
See how protocol work can fit established SPRAVATO®, ketamine, and TMS operations.
Research Sponsors