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Research

Research for participants and sponsors

Explore current studies, learn what participation may involve, and review Mood Institute's research capabilities.

Contact research teamView current studies

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Find clear information about services, treatments, research, and practical next steps.

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For research participants

Review current studies and learn what participation may involve.

How research participation works
Recruiting

PCORI Study: IV Ketamine vs Esketamine for Treatment-Resistant Depression

This pragmatic clinical trial compares the effectiveness, safety, and patient experience of IV ketamine and intranasal esketamine in adults with treatment-resistant depression.

Study ID
NCT06713616
Phase
Comparative Effectiveness
Focus
Treatment-resistant depression
Interventions
IV Ketamine · SPRAVATO® (esketamine)
Ages
18+
Locations
Milford, CT
  • Compare IV ketamine with SPRAVATO® (esketamine)
  • Assess symptom change after eight treatments
  • Evaluate safety and tolerability
Learn moreSee if I'm eligible
Recruiting

OBSERVE Study: Real-World Outcomes in Depression Care

An observational study tracking outcomes and treatment patterns in individuals receiving care for depression in real-world clinical settings.

Study ID
NCT06725277
Phase
Observational
Focus
Real-world outcomes
Interventions
IV ketamine · SPRAVATO® (esketamine)
Ages
18+
Locations
Milford, CT
  • Observational study of prescribed care
  • Track treatment patterns, safety, and effectiveness over time
  • Contribute to evidence about real-world depression care
Learn moreSee if I'm eligible
View all studies

Study status and criteria can change. Verify current details on the official ClinicalTrials.gov record.

For research sponsors

A trusted partner for high-quality psychiatric research. Mood Institute supports feasibility through execution for mood-disorder studies in Connecticut.

Partner with us

  • Expert investigators

    Board-certified psychiatrists with academic appointments and extensive research experience.

  • Qualified participants

    Access to a diverse patient population with mood disorders and high treatment engagement.

  • Operational excellence

    Efficient study start-up, rigorous protocol adherence, and participant-centered care.

  • Comprehensive capabilities

    From feasibility and site selection to execution and data collection — end-to-end support.

Why partner with Mood Institute?

Our investigators

Lisa Harding, MD

Site Principal Investigator

Board-certified psychiatrist with clinical and research experience in interventional psychiatry and complex mood disorders. Assistant Clinical Professor context at Yale School of Medicine (public practice narrative).

Terrell Holloway, MD

Site Sub-Investigator

Psychiatrist with expertise in mood disorders, trauma-informed care, and interventional treatments. Experienced in clinical trials and evidence-based care.

Practice and patient information

Locations
Milford, CT · Southport, CT
Population focus
Depression, bipolar disorder, anxiety, OCD, ADHD
Age range
Adolescents (16+) · Adults
Treatment modalities
Medications, IV ketamine, TMS, SPRAVATO®, psychotherapy collaboration

Demographic and feasibility details are available upon request for qualified research partners. Figures are institutional and aggregate only—no participant-level data is published on this website.

View full site qualifications

Let's advance research together.

Contact our research team to discuss feasibility, timelines, and partnership opportunities.

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